Publications

2012

  • Reed, J., White, L., Aube, J., Lindsley, C.,Li, M., Sklar, L., & Schreiber, S., The NIH’s role in accelerating translational sciences. Nature Biotechnology 30:16-19 (2012)
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  • Xiang., Z. et al., The Discovery and Characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson’s Diseases. ACS Chemical Neuroscience (accepted) (2012)
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2011

  • Du, F., Yu, H., Zou, B., Babcock, J., Long, S., Li, M., hERGcentral: A large database to store, retrieve, and analyze compound-human ether-a-go-go related gene channel interactions to facilitate cardiotoxicity assessment in drug development. Assay Drug Dev. Technol. 9:580-588 (2011) (Cover Article)
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  • Yu, H., Wu, M., Townsend, S.D., Zou, B., Long, S., Daniels, J.S., Lindsley, C.W., Hopkins, C.R. McManus, O.B., Li, M. Discovery, synthesis, and structure-activity relationship of a series of N-Aryl-bicyclo[2.2.1]heptanes-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem Neuroscience DOI: 10.1021/200065b (2011)
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  • Miller, M., Shi, J., Zhu, Y., Kustov, M., Tian, J., Stevens, A., Wu, M., Xu, J., Long, S., Yang, P., Zholos, A.V., Salovich, J.M., Weaver, D.C., Hopkins, C.R., Lindsley, C.W., McManus, O.B., Li, M., Zhu, M.X. Identification of ML204 – a novel potent antagonist that selectively modulates native TRPC4/C5 channels. J Biol Chem 286(38), 33436-46 (2011)
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  • Wang, H., Wu, M., Yu, H., Long, S., Stevens, A., Engers, D.W., Sackin, H., Daniels, J.S., Dawson, E.S., Hopkins, C.R., Lindsley, C.W., Li, M., McManus, O.B. Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: The discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol 6(8), 845-56 (2011)
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  • Deng, P., Pang, P., Lei, Z., Shikano, S., Xiong, Q., Harvey, B., London, B., Wang, Y., Li, M., & Xu, Z. Up-regulation of A-type potassium currents protects neurons against cerebral ischemia. J. Cerebral Blood Flow and Metabolism 1-13 (2011) (Featured Article)
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  • Kato, M., Chiba, T., Li, M., and Hanyu, Y. Bioluminescence Assay for Detecting Cell Surface Membrane Protein Eexpression. Assay Drug Dev. Technol. ahead of print. PMID: 20836709 (2011)
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2010

  • Zou, B., Yu, H., Babcock, J.J., Chanda, P., Bader, J.S., McManus, O.B., and Li, M. Profiling diverse compounds by flux-based and electrophysiology-based primary screens for inhibition of hERG potassium channels. Assay Drug Dev. Technol. 8(6), 743-754 (2010) (Cover article accompanied with PROFILE interview)
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  • Profile: An Interview with Dr Min Li. Assay Drug Dev. Technol. 8:631-637 (2010)
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  • Gao, Z., Zhang, T., Wu, M., Xiong, Q., Sun, H., Zhang, Y., Zu, L., Wang, W., and Li, M. Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions. J Biol Chem 210(36), 28322-28332 (2010)
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  • Hou, S., Vigeland, L. E., Zhang, G., Xu, R., Li, M., Heinemann, S. H., and Hoshi, T. Zn2+ Activates Large Conductance Ca2+-activated K+ Channel via an Intracellular Domain. J Biol Chem 285(9), 6434-6442 (2010)
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  • Li, M. and McManus, O.B. Ion Channel Targets Meeting Review – Select Biosciences (2010)
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  • Miller,M., Wu,M., Xu,J., Weaver,D., Li, M., Zhu, M-X. High-throughput screening of TRPC channel ligands using cell-based assays TRP Channels - Assays and Protocols (2010).
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2009

  • Zachos, N. C., Li, X., Kovbasnjuk, O., Hogema, B., Sarker, R., Lee, L. J., Li, M., de Jonge, H., and Donowitz, M. Contributes to Basal and Calcium Inhibition of NHE3 Activity in Caco-2BBe Cells. J Biol Chem 284(35), 23708-23718 (2009)
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  • Wu, M., Long, S., Frutos, A. G., Eichelberger, M., Li, M., and Fang, Y. Interrogation of phosphor-specific interaction on a high-throughput label-free optical biosensor system-Epic System. J Recept Signal Transduct Res 29(3-4), 202-210 (2009)
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  • Chung, J. J., Okamoto, Y., Coblitz, B., Li, M., Qiu, Y., and Shikano, S. PI3K/Akt signaling-mediated protein surface expression sensed by 14-3-3 interacting motif. FEBS J 276: 5547-5558 (2009)
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2008

  • Eichelberger, M. C., Hassantoufighi, A., Wu, M. and Li, M., Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay. Virology Journal 5:109-117 (2008)
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  • Gao, Z., Xiong, Q., Sun, H., and Li, M., Desensitization of Chemical Activation by Auxiliary Subunits: Convergence of Molecular Determinants Critical for Augmenting KCNQ1 Potassium Channels. J Biol Chem 283:22649-22658 (2008)
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  • Xiong, Q., Sun, H., Nan, F. and Li, M., Combinatorial Activation of KCNQ potassium channels by synthetic chemical ligands. Proc. Natl. Acad. Sci. USA 105, 3128-3133 (2008)
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  • Xiong, Q., Gao, Z., Wang, W. and Li, M., Activation of Kv7 (KCNQ) potassium channels by chemical openers. Trends Pharmacol Sci 29, 99-107 (2008)
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2007

  • Li, J., et al., Spatiotemporal Coupling of cAMP Transporter to CFTR Chloride Channel Function in the Gut Epithelia. Cell 30; 131(5): 940–951 (2007)
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  • Xiong, Q., Sun, H., and Li, M., Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nature Chemical Biol. 3, 287-296 (2007)
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  • Rong, J., Li, S., Sheng, G., Wu, M., Coblitz, B., Li, M., Fu, H., and Li, X. J. 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking. J Biol Chem 282, 4748-4756 (2007)
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  • Ma, D., Nakata, T., Zhang, G., Hoshi, T., Li, M., and Shikano, S. Differential trafficking of carboxyl isoforms of Ca(2+)-gated (Slo1) potassium channels. FEBS Letters. 581, 1000-1008 (2007)
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2006

  • Salinas, G.D., Blair, L.A., Needleman, L.A., Gonzales, J.D., Chen, Y., Li, M., Singer, J.D. and Marshall, J. Actinfilin is a CUL3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway. J Biol Chem.(accepted and published online)(2006)
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  • Wu, M., Coblitz, B., Shikano, S., Long, S., Spieker, M., Frutos, A.G., Mukhopadhyay, S. and Li, M. Phospho-specific recognition by 14-3-3 proteins and antibodies monitored by a high throughput label-free optical biosensor. FEBS Lett, 580, 5681-5689 (2006)
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  • Shikano, S. Coblitz, B., Wu, M. & Li, M. 14-3-3 proteins: regulation of ER localization and surface expression of membrane proteins. Trends in Cell Biol 16, 370-375 (2006)
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  • Sun, H., Liu, X., Shikano, S, and Li, M. Chronic inhibition of cardiac Kir2.1 and hERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking. J. Biol. Chem. 281, 5877-5884 (2006; featured cover story, Paper of the week)
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  • Coblitz, B., Wu, M., Shikano, S., and Li, M. C-terminal binding: An expanded repertoire and function of 14-3-3 proteins. FEBS Letters. 580, 1531-1535 (2006)
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  • Wu, M., Coblitz, B., Shikano, S., Cockrell, L.M., Fu, H., and Li, M. SWTY – A general peptide probe for homogeneous solution binding assay of 14-3-3 proteins. Anal Biochem. 349, 186-196 (2006)
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2005

  • Coblitz, B., Shikano, S., Wu, M., Gabelli, S.B., Cockrell, L.M., Spieker, M., Hanyu, Y., Fu, H., Amzel, L.M., and Li, M. C-terminal recognition by 14-3-3 proteins for surface expression of membrane proteins. J. Biol. Chem. 280, 36263-36272 (2005)
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  • Shikano, S. Coblitz, B., Sun, H. & Li, M. Genetic selection of trafficking signals that direct cell surface expression. Nat Cell Biol. 7, 985-992 (2005)
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  • Chen, Y. & Li, M. Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons. Neuropharmacology 49, 1026-1041 (2005)
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  • Chung, J, Li, M. Purification of native Kv2.1 potassium channel-evidence for heterogeneous subunit composition. FEBS J. 272, 3743-3755 (2005)
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  • Li, M. High Throughput compound screening and discovery in academic setting. Retina 25: 58-59 (2005)
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2004

  • Xu, J, Chen,Y, Li, M. High-throughput technologies for studying potassium channels – progresses and challenges. Targets, 3, 32-38.(2004)
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  • Sun,H, Shikano, S, Xiong,Q, Li, M. Function recovery after chemobleaching (FRAC): Evidence for activity silent membrane receptors on cell surface. Proc. Natl. Acad. Sci. USA.101, 16964-16969(2004)
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2003

  • Wang, X. & Li, M. Automated electrophysiology: high throughput of art. Assays and Drug Development Technologies 1:695-708 (2003)
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  • Shikano, S. & Li, M. Membrane receptor trafficking: Evidence of proximal and distal zones conferred by two independent endoplasmic reticulum localization signals. Proc. Natl. Acad. Sci. USA. 100, 5783-5788 (2003)
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  • Chung, J.J., Yang, H., & Li, M. Genome-wide analyses of carboxylated terminal sequences of yeast proteins. Mol Cell Proteomics 2, 173-81 (2003)
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2002

  • Chen, Y., Derin, R., Petralia, R.S. & Li, M. Actinfilin – A brain-specific kelch actin-binding protein in postsynaptic density. J. Biol. Chem 277: 30495-30501 (2002)
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  • Chung, J. J., Shikano, S., Hanyu, Y. & Li, M. Functional diversity of protein C-termini: more than zipcoding? Trends Cell Biol 12, 146-50. (2002)
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  • Cheng, J., Moyer, B. D., Milewski, M., Loffing, J., Ikeda, M., Mickle, J. E., Cutting, G. R., Li, M., Stanton, B. A., & Guggino, W. B. A GOLGI associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. J Biol Chem 13, 13 (2002)
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  • Xu, J., Wang, X., Ensign, B., Li, M., Wu, L., Guia A., and Xu, J. Ion-channel assay technologies: quo vadis? Drug Discovery Today 6, 1278-1287 (2002)
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2001

  • Ma, D. & Li, M. Applications of display technologies to proteomic analyses. J Cell Biochem 37, 34-41. (2001).
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  • Wang, S., Yue, Y., Derin, R., Guggino, W., and Li, M. Regulation of CFTR activity via protein-protein interactions. Pediatric Pulmonology 22, 87 (2001).
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  • Wang, S. & Li, M. Molecular studies of CFTR interacting proteins. Pflugers Arch 443, 62-4. (2001)
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  • Worley, J. & Li, M. Location is key - recent progress in single-cell-based high-throughput assays. Drug Discov Today 6, 454. (2001).
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  • Wang, S. & Li, M. Molecular Studies of CFTR interacting proteins. Eur. J. Physiol 443, 62-64 (2001).
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2000

  • Wang, S., Yue, H., Derin, R. B., Guggino, W. B. & Li, M. Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell 103, 169-79. (2000).
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  • Tang, Y. Tang, J., Chen, Z., Trost, C., Flockerzi, V., Li, M., Ramesh, V., & Zhu, M. X. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem 275, 37559-64. (2000).
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  • Moyer, B. D. Duhaime, M., Shaw, C., Denton, J., Reynolds, D., Karlson, K. H., Pfeiffer, J., Wang, S., Mickle, J. E., Milewski, M., Cutting, G. R., Guggino, W. B., Li, M. & Stanton, B. A. The PDZ-interacting domain of cystic fibrosis transmembrane conductance regulator is required for functional expression in the apical plasma membrane. J Biol Chem 275, 27069-74. (2000).
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  • Li, M. Applications of display technology in protein analysis. Nat Biotechnol 18, 1251-6. (2000).
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  • Li, M. & Adelman, J. P. ChIPping away at potassium channel regulation. Nat Neurosci 3, 202-4. (2000).
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1999

  • van Huizen, R., Czajkowsky, D. M., Shi, D., Shao, Z. & Li, M. Images of oligomeric Kv beta 2, a modulatory subunit of potassium channels. FEBS Lett 457, 107-11. (1999).
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  • Moyer, B. D., Denton, J., Karlson, K. H., Reynolds, D., Wang, S., Mickle, J. E., Milewski, M., Cutting, G. R., Guggino, W. B., Li, M. & Stanton, B. A. A PDZ-interacting domain in CFTR is an apical membrane polarization signal. J Clin Invest 104, 1353-61. (1999).
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  • Jo, K., Derin, R., Li, M. & Bredt, D. S. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN- 7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. J Neurosci 19, 4189-99. (1999).
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  • Gong, J., Xu, J., Bezanilla, M., van Huizen, R., Derin, R., & Li, M. Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Science 285, 1565-9. (1999).
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  • Whitehorn, E., Dower, W. and Li. M. Expression of extracellular N-terminal domain of NMDA receptor in mammalian cells. Methods in Molecular Biology. NMDA Receptor Protocols (Humana Press) 128, 61-72 (1999)
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  • Cwirla, S., Dower, W. and Li, M. In vitro selection of peptides acting on NMDA receptors. Methods in Molecular Biology, NMDA Receptor Protocols (Humana Press), 128, 131-141 (1999)
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  • Stricker, N. L., Schatz, P. & Li, M. Using the Lac repressor system to identify interacting proteins. Methods Enzymol 303, 451-68 (1999)
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1998

  • Xu, J. &. Li, M. Auxiliary subunits of Shaker-type potassium channels. Trends in Cardiovascular Medicine 8, 229-234 (1998).
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  • Xu, J., Yu, W., Wright, J. M., Raab, R. W. & Li, M. Distinct functional stoichiometry of potassium channel beta subunits. Proc Natl Acad Sci U S A 95, 1846-51. (1998).
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  • Wang, S., Raab, R. W., Schatz, P. J., Guggino, W. B. & Li, M. Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C- terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR). FEBS Lett 427, 103-8. (1998).
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  • van Huizen, R. Miller, K., Chen, D. M., Li, Y., Lai, Z. C., Raab, R. W., Stark, W. S., Shortridge, R. D., and Li, M. Two distantly positioned PDZ domains mediate multivalent INAD- phospholipase C interactions essential for G protein-coupled signaling. Embo J 17, 2285-97. (1998).
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  • Tu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J. and Worley, P. F. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21, 717-26. (1998).
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  • Morais Cabral, J. H. Lee, A., Cohen, S. L., Chait, B. T., Li, M., and Mackinnon, R. Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell 95, 649-55. (1998).
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  • Xu, J. & Li, M. Methods used to study subunit assembly of potassium channels. Methods Enzymol 293, 3-17 (1998)
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1997

  • Min Li (Editor), Methods of Molecular Biology, NMDA Receptor, Humana Press (1997)
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  • Xu, J. & Li, M. Kvbeta2 inhibits the Kvbeta1-mediated inactivation of K+ channels in transfected mammalian cells. J Biol Chem 272, 11728-35. (1997).
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  • Stricker, N. L. Christopherson, K. S., Yi, B. A., Schatz, P. J., Raab, R. W., Dawes, G., Bassett, D. E., Jr., Bredt, D. S., Li, M. PDZ domain of neuronal nitric oxide synthase recognizes novel C- terminal peptide sequences. Nat Biotechnol 15, 336-42. (1997).
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  • Li, X., Xu, J. & Li, M. The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression. J Biol Chem 272, 705-8. (1997).
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  • Li, M. Use of a modified bacteriophage to probe the interactions between peptides and ion channel receptors in mammalian cells. Nat Biotechnol 15, 559-63. (1997).
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1996

  • Yu, W., Xu, J. & Li, M. NAB domain is essential for the subunit assembly of both alpha-alpha and alpha-beta complexes of shaker-like potassium channels. Neuron 16, 441-53. (1996).
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  • Li, M., Yu, W., Chen, C. H., Cwirla, S., Whitehorn, E., Tate, E., Raab, R., Bremer, M., and Dower, B.. In vitro selection of peptides acting at a new site of NMDA glutamate receptors. Nat Biotechnol 14, 986-91. (1996).
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1995

  • Xu, J., Yu, W., Jan, Y. N., Jan, L. Y. & Li, M. Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha- subunits. J Biol Chem 270, 24761-8. (1995).
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1994

  • Li, M., Unwin, N., Stauffer, K. A., Jan, Y. N. & Jan, L. Y. Images of purified Shaker potassium channels. Curr Biol 4, 110-5. (1994).
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1993

  • Li, M., Isacoff, E., Jan, Y. N. & Jan, L. Y. Assembly of potassium channels. Ann N Y Acad Sci 707, 51-9. (1993).
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1992

  • Li, M., Jan, Y. N. & Jan, L. Y. Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science 257, 1225-30. (1992).
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  • Li, M., and Desiderio, S. Physical characterization of DNA-Binding proteins in crude preparations. Transcription Factors-A practical approach. (Oxford Press), 181-196. (1992).
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  • Baldwin, T. J. Isacoff, E.., Li, M., Lopez, G. A., Sheng, M., Tsaur, M. L., Yan, Y. N., & Jan, L. Y. Elucidation of biophysical and biological properties of voltage-gated potassium channels. Cold Spring Harb Symp Quant Biol 57, 491-9 (1992).
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1989

  • Vernachio, J., Li, M., Donnenberg, A. D. & Soloski, M. J. Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset. J Immunol 142, 48-56. (1989).
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  • Li, M., Morzycka-Wroblewska, E. & Desiderio, S. V. NBP, a protein that specifically binds an enhancer of immunoglobulin gene rearrangement: purification and characterization. Genes Dev 3, 1801-13. (1989).
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1988

  • Lee, S., Li, M. & Pollard, T. D. Evaluation of the binding of Acanthamoeba profilin to pyrene-labeled actin by fluorescence enhancement. Anal Biochem 168, 148-55. (1988).
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